2 Oct 2002 ... Agrin is synthesized by motoneurons, transported down axons, and secreted into the synaptic cleft. There it organizes or induces differentiation ...
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Injection of wild-type or mutated agrin into rat soleus muscle induced the formation ... These results indicate that the mutation does not interfere with the ability of agrin to ... Further investigations will be needed to pin down the detailed molecular ... Sobel A., Heidmann T., Hofler J., Changeux J.P. Distinct protein components ...
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9 Jan 2013 ... The agrin/muscle-specific kinase (MuSK) pathway is critical for proper ... Fluorescence intensity quantification of MuSK was not feasible on whole mount ... a touch-down protocol including a hybridization step at 65°C to 55°C (10 cycles, ... Sobel A, Heidmann T, Hofler J, Changeux JP (1978) Distinct protein ...
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21 Sep 2012 ... Briefly, agrin-induced fold enrichment of Chrna1 mRNA in pull down ... In agreement with previous studies [23], [24], agrin did not alter the levels of ... J.P. Merlie, J.R. SanesConcentration of acetylcholine receptor mRNA in ...
2 Aug 2005 ... Although activation of AChRs can down-regulate AChR subunit gene ... The effect of agrin was specific in that no AChR aggregates formed at sites of ... R. H., Merlie, J. P. & Sanes, J. R. (1996) Cell 85 , 525-535. pmid:8653788.
12 Apr 2010 ... Down-regulation of CRMP2 expression dampened the ... Furthermore, purified Agrin from activated, but not resting, T cells when added to the ... Gautam M, Noakes PG, Moscoso L, Rupp F, Scheller RH, Merlie JP, Sanes JR: ...
the extent of agrin cleavage and the rate of NMJ maturation. Intriguingly ... that the higher levels of agrin slowed down, but did not prevent, ... J. P. (1995). Failure ...
1 Feb 2012 ... In MuSK−/− mice, muscle fibers do not form neural clusters or “prepattern” ... GST pull-down assays were performed between GST-agrin .
29 Jan 2015 ... Agrin enhances cellular proliferation, migration and oncogenic ... However, not many ECM proteins except collagen can modulate ... Using 10%, 90% and in-between quantile-based thresholds, the proteins were categorized as down-, ... Nature China · Nature India · Nature Japan · Nature Korea · Nature ...
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Isoform 5, agrin (z 8), containing the 8-AA insert, forms a receptor complex in ... does not affect phosphorylation of MUSK; does not affect AChR clustering.
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