21 Sep 2012 ... Briefly, agrin-induced fold enrichment of Chrna1 mRNA in pull down ... In agreement with previous studies [23], [24], agrin did not alter the levels of ... J.P. Merlie, J.R. SanesConcentration of acetylcholine receptor mRNA in ...
After nigrostriatal lesions with either MPTP or 6-hydroxydopamine, α6 and β3 ... Receptor up- and down-regulation is not only controlled by the nature of the ...
Injection of wild-type or mutated agrin into rat soleus muscle induced the formation ... These results indicate that the mutation does not interfere with the ability of agrin to ... Further investigations will be needed to pin down the detailed molecular ... Sobel A., Heidmann T., Hofler J., Changeux J.P. Distinct protein components ...
Oxidized phospholipids in oxidized low-density lipoprotein down-regulate ... respectively, and did not significantly differ from that in the cells treated with DRB alone. ... A number of OxPL receptors (PAF receptor, CD36 scavenger receptor BI, ...
... Medicine Hannover, Foundation, Germany. [email protected] ... In addition, a down-regulation of Cyp19A1, the rate-limiting enzyme of ... Furthermore, BMP-6 did not affect the activity of the mitogen-activated protein kinase.
2 Aug 2005 ... Although activation of AChRs can down-regulate AChR subunit gene ... The effect of agrin was specific in that no AChR aggregates formed at sites of ... R. H., Merlie, J. P. & Sanes, J. R. (1996) Cell 85 , 525-535. pmid:8653788.
2 Oct 2002 ... Agrin is synthesized by motoneurons, transported down axons, and secreted into the synaptic cleft. There it organizes or induces differentiation ...
9 Jan 2013 ... The agrin/muscle-specific kinase (MuSK) pathway is critical for proper ... Fluorescence intensity quantification of MuSK was not feasible on whole mount ... a touch-down protocol including a hybridization step at 65°C to 55°C (10 cycles, ... Sobel A, Heidmann T, Hofler J, Changeux JP (1978) Distinct protein ...
the extent of agrin cleavage and the rate of NMJ maturation. Intriguingly ... that the higher levels of agrin slowed down, but did not prevent, ... J. P. (1995). Failure ...
12 Apr 2010 ... Down-regulation of CRMP2 expression dampened the ... Furthermore, purified Agrin from activated, but not resting, T cells when added to the ... Gautam M, Noakes PG, Moscoso L, Rupp F, Scheller RH, Merlie JP, Sanes JR: ...
5 Aug 2020 ... “With our combined efforts, we know there is no health challenge that we ... To learn more about Pfizer Canada, visit pfizer.ca or you can follow us on ... and off-the-shelf mRNA-based therapies, innovative chimeric antigen ...
1 Mar 2018 ... However, leptin had no significant effect on osteoblast proliferation, ... It was confirmed that leptin can promote osteoblast mineralization and down-regulate the RANKL mRNA expression. ... 16PJ234, http://www.scwst.gov.cn/).
... liver and HepG2 cells and that 50% reduction of FGA mRNA levels would not ... performed siRNA-mediated down-regulation of the fibrinogen gene in HepG2 ... mRNA levels were determined using real-time quantitative RT- PCR for three ...
the physician do not influence CD rates. Group practice may reduce ... www.AJOG.org. S148 American Journal of Obstetrics & Gynecology Supplement to JANUARY 2012 ... significantly down regulated with increasing obesity. Other genes.
The Puf repeat domain of Puf3p is sufficient not only for in vitro binding to the 3 UTR, ... at http://www.rnajournal.org/cgi/doi/10.1261/rna.7270204. RNA (2004) ...
In clinical breast cancers, down-regulation of BRMS1 expression seems not to ... Juan Carlos, Facultad de Ciencias de la Salud, Madrid [email protected].
1 Jul 2017 ... Down syndrome (DS), also known as trisomy 21, is a genetic ... There is no effective treatment for DS so far, and guidelines ... Mersy E, Smits LJ, van Winden LA, de Die-Smulders CE South-East Netherlands NIPT Consortium.
1 Feb 2012 ... In MuSK−/− mice, muscle fibers do not form neural clusters or “prepattern” ... GST pull-down assays were performed between GST-agrin .
29 Jan 2015 ... Agrin enhances cellular proliferation, migration and oncogenic ... However, not many ECM proteins except collagen can modulate ... Using 10%, 90% and in-between quantile-based thresholds, the proteins were categorized as down-, ... Nature China · Nature India · Nature Japan · Nature Korea · Nature ...
25 Feb 2020 ... [email protected] (F.F.); [email protected] (M.M.); [email protected] (R.F.); ... We found that 1-month treatment with ticagrelor, but not clopidogrel, led to increased ... (8/21 and 9/21, up- and down-regulated, respectively) (Figure 3B).
down-regulation of ER- that is not attributable to de- creased ... However, ER-–negative status in in situ cancer is associated ... clincancerres.aacrjournals.org.
15 Jul 2020 ... ... of NGEN in cell death of lung cancer cells have not been fully defined. ... intensely upregulated Bax and down‐regulated Bcl‐2 proteins were ...
https://doi.org/10.1016/j.bbamcr.2007.04.013Get rights and content ... The human prostate carcinoma cell line PC-3 (Passage 18) was obtained from the ... For COX-2 the down-regulation by the mutant prostasin was not as great as that by the ...
proLékaře.cz proLékaře.cz ... The cellular clearance pathways, e.g. autophagy-lysosomal pathway, may not be of high efficiency in the ... In the absence of ULK1, anti-ULK1 antibody did not pull down p62 in ULK1 knock-out(KO) MEFs [38], ...
9 Feb 2008 ... Fax: 3 2118365. E-mail address: [email protected] (C.-M. Yang). ... MMP-2 is constitutively expressed by several cell types and not inducible ... MEK1 and p42 down-regulated the expression of MEK1 and p42 and ...
Increase in albuminuria was significant in 129/Sv but not in C57BL/6JRj mice. ... but these models do not fully reproduce the CV consequences of CKD observed in humans, ... Transplant. Off. Publ. Eur. Dial. Transpl. Assoc. - Eur. Ren. Assoc., https://doi. ... Timmermans, S., Van Montagu, M. & Libert, C. Complete overview of ...
15 Jun 2003 ... ... (12) 6024-6032; DOI: https://doi.org/10.4049/jimmunol.170.12.6024 ... Receptor down-regulation could also be inhibited by blockage of Src family kinase activity. ... Induction of Cbl phosphorylation upon ephrin-A stimulation, but not ... Miao, H., B. R. Wei, D. M. Peehl, Q. Li, T. Alexandrou, J. R. Schelling, ...
30 Jan 2020 ... Heart weight increased significantly only in 129/Sv mice. ... Increase in albuminuria was significant in 129/Sv but not in C57BL/6JRj mice. Both strains ... Off. Publ. Eur. Dial. Transpl. Assoc. - Eur. Ren. Assoc. 26, 3537–3543 (2011). ... Timmermans, S., Van Montagu, M. & Libert, C. Complete overview of ...
1 Sep 2018 ... Electronic address: [email protected]. ... NS3-4A and NS4A proteins were not only localized on ER but also on the mitochondria. ... expression of Bax and down-regulated expression of anti-apoptotic Bcl-xL protein ...
7 Oct 2013 ... Small interfering RNA was used to knock down c‐Fos. ... available at http://www.saitama‐med.ac.jp/uinfo/riumachi/supplementary_figure.html). ... Dependence of osteoclast‐like cells, but not conventional osteoclasts, on JAK.
Science and Technology, China Medical University, No 91, Hsueh-Shih. Road, Taichung ... 5850, Fax: 886 228264517, e-mail: [email protected]. Key Words: Ouabain ... death, via Mcl-1 down-regulation (8). Moreover, inhibition of.
Published Online:15 Jun 2016https://doi.org/10.1091/mbc. ... However, how hyperthermia induces DNA damage sensitivity is not clear. ... Hsp90 causes down-regulation of Rad53 in a dose-dependent manner ... article was published online ahead of print in MBoC in Press (http://www.molbiolcell.org/cgi/doi/10.1091/mbc.
26 Mar 2015 ... 11 Advanced Medical Research Center, Yokohama City University, Yokohama, Kanagawa, 236-0004, Japan. [email protected].
23 May 2017 ... Three dogs did not contribute with samples from all diet periods due to a faecal score > 4.5 two consecutive times. One dog (no. 8) was taken off ...
While there is not a one-to-one correlation with any gene set from a published ... S1; supplementary data are available online at www.liebertonline.com/ast). ... In those same root samples, 121 proteins were found to be down-regulated and ...
5 Jul 2016 ... The frequent finding of post-TAVI thrombocytopenia appears not to be ... and platelet activation after on-pump and off-pump coronary artery ...
... however, their molecular mechanisms in vitro and in in vivo models are not well studied. ... Chungnam National University, Daejeon 301747, Korea. [email protected] ... Rh2-induced apoptosis was accompanied by the down-regulation of ...
28 Mar 2019 ... Staining intensity was scored according to the following criteria: 0 (no staining, negative); 1 ... Sk‐hep1 cells of density of 4.0 × 104 cells/mL were cultured in Eagle's ... Technologies, Kumamoto, Japan) according to the manufacturer's protocols. ... Conversely, knocking down of LOX did not suppress HIF‐1α ...
7 Feb 2019 ... ... Tokushima 770-8504, Japan. [email protected]. ... thermal nociception, glial activity, and down-regulated IL-1β and IL-6 cytokines ...
8 May 2019 ... (A) The sea anemone Anemonia viridis growing at high CO2 (mean pH 7.6) at 1 m depth. ... We infer that the host-symbiont relationship is not disrupted at low ... Down-regulation of transcripts from seawater pH 8.2 to either pH 7.6 or pH ... Moya A, Huisman L, Foret S, Gattuso JP, Hayward DC, Ball EE, et al.
(cleaved forms expressed) but not caspase 8. ... The authors declare that there are no conflicts of interest. ... Down-regulation of Bim expression relationship.
Isoform 5, agrin (z 8), containing the 8-AA insert, forms a receptor complex in ... does not affect phosphorylation of MUSK; does not affect AChR clustering.
Kaohsiung County 831, Taiwan, Graduate Institute of Medical Biotechnology, Chang ... [email protected] (S.-H.K.). ... whether or not 6-SG can exert a carcinogenic effect. ... reactive oxygen species and down-regulation of NF-κB signaling.
ultimate effect of NO on tumor cell survival is dictated by multiple factors, including levels of NO ... [email protected], [email protected]. (K.-L. Chang). ... incubated with drugs for 6 h, scraped off and centrifuged. The cell pellet was ...
24 Jun 2019 ... In vivo, drinking coffee (but not water) stimulated the temperature of the supraclavicular region, which co-locates to the main region of BAT in ...
